Jolanda van Leeuwen
University of Lausanne, UMass Chan Medical School
Biography
Jolanda van Leeuwen received her PhD from VU University Amsterdam (the Netherlands), where her research uncovered genetic factors influencing the toxicity of non-steroidal anti-inflammatory drugs. Following her doctorate in 2011, she joined the laboratories of Dr. Charlie Boone and Dr. Brenda Andrews at the University of Toronto (Canada). Supported by a postdoctoral fellowship from the Canadian Institutes of Health Research, she mapped genetic interaction networks in yeast. In April 2018, Jolanda became an Assistant Professor at the Center for Integrative Genomics, University of Lausanne (Switzerland), earning tenure in 2024. That same year, she moved to the Department of Systems Biology at UMass Chan Medical School as Associate Professor. The main research mission of her lab is to use functional genomics tools to improve our understanding of how mutations can interact to produce unexpected phenotypes, and how this determines the severity of genetic traits, including human disease.
Relevant Publications
- A global genetic interaction map of a human cell reveals conserved principles of genetic networksBillmann M., Costanzo M., Zhang X., Hassan A.Z., Rahman M., Brown K.R., Chan K.S., Tong A.H.Y., Pons C., Ward H.N., bioRxiv (2025).
- Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screensBillmann M., Costanzo M., Rahman M., Chan K., Tong A.H.Y., Ward H.N., Hassan A.Z., Zhang X., Brown K.R., Rohde T., bioRxiv (2025).
- The modifiers that cause changes in gene essentialityBatté A., Bosch-Guiteras N., Pons C., Ota M., Lopes M., Sharma S., Tellini N., Paltenghi C., Conti M., Kan K.T., bioRxiv (2025).
- Genetic suppression interactions are highly conserved across genetically diverse yeast isolatesPaltenghi C., van Leeuwen J., G3 (Bethesda) (2025).
- Meta-analysis of dispensable essential genes and their interactions with bypass suppressorsPons C., van Leeuwen J., Life Sci Alliance (2023).
- Global analysis of suppressor mutations that rescue human genetic defectsÜnlü B., Pons C., Ho U.L., Batté A., Aloy P., van Leeuwen J., Genome Medicine (2023).
- Natural variants suppress mutations in hundreds of essential genesParts L., Batté A., Lopes M., Yuen M.W., Laver M., San Luis B.J., Yue J.X., Pons C., Eray E., Aloy P., Molecular Systems Biology (2021).
- Systematic analysis of bypass suppression of essential genesvan Leeuwen J., Pons C., Tan G., Wang J.Z., Hou J., Weile J., Gebbia M., Liang W., Shuteriqi E., Li Z., Molecular Systems Biology (2020).
- Evaluation and design of genome-wide CRISPR/Cas9 knockout screensHart T., Tong A.H.Y., Chan K., van Leeuwen J., Seetharaman A., Aregger M., Chandrashekhar M., Hustedt N., Seth S., Noonan A., G3 (Bethesda) (2017).
- Exploring genetic suppression interactions on a global scalevan Leeuwen J., Pons C., Mellor J.C., Yamaguchi T.N., Friesen H., Koschwanez J., Mattiazzi Ušaj M., Pechlaner M., Takar M., Ušaj M., Science (2016).