Jonathan Schmid Burgk

Relevant Publications

• NIS-Seq enables cell-type-agnostic optical perturbation screening
  Fandrey C.I., Jentzsch M., Konopka P., Hoch A., Blumenstock K., Zackria A., Maasewerd S., Lovotti M., Lapp D.J., Gohr F.N., Nature Biotechnology (2024).
  https://doi.org/10.1038/s41587-024-02516-5
• LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding
  Ludwig K.U., Schmithausen R.M., Li D., Jacobs M.L., Hollstein R., Blumenstock K., Liebing J., Słabicki M., Ben-Shmuel A., Israeli O., Nature Biotechnology (2021).
  https://doi.org/10.1038/s41587-021-00965-6
• Highly parallel profiling of Cas9 variant specificity
  Schmid-Burgk J.L.*, Gao L.*, Li D.*, Gardner Z., Strecker J., Lash B., Zhang F., Molecular Cell (2020).
• Sensing endogenous RNA in living human cells using a CRISPR-activated protease
  Blumenstock K., Hoch A., Hinterlang L.D., Fandrey C.I., Schneberger N., Hagelueken G., Schmid-Burgk J.L., bioRxiv (2024).
  https://doi.org/10.1101/2024.07.17.603943
• Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells
  Hoch A., Fandrey C.I., Coventry B., Virreira Winter S., Geyer P.E., Kempchen T.N., Ebert T.S., Hölzel M., Baker D., Schmid-Burgk J.L., bioRxiv (2025).
  https://doi.org/10.1101/2025.05.11.653342
• A genome-wide CRISPR screen identifies NEK7 as an essential component of NLRP3 inflammasome activation
  Schmid-Burgk J.L., Chauhan D., Schmidt T., Ebert T.S., Reinhardt J., Endl E., Hornung V., Journal of Biological Chemistry (2016).
• BrowserGenome.org: web-based RNA-seq data analysis and visualization
  Schmid-Burgk J.L., Hornung V., Nature Methods (2015).
• Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells
  Schmid-Burgk J.L.*, Gaidt M.M.*, Schmidt T.*, Ebert T.S.*, Bartok E., Hornung V., European Journal of Immunology (2015).
• OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines
  Schmid-Burgk J.L.*, Schmidt T.*, Gaidt M.M., Pelka K., Latz E., Ebert T.S., Hornung V., Genome Research (2014).
• A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes
  Schmid-Burgk J.L.*, Schmidt T.*, Kaiser V., Höning K., Hornung V., Nature Biotechnology (2013).