Manuel Kaulich
Goethe University, Frankfurt
Biography
Manuel is a functional and computational biologist at the Goethe University Frankfurt in Germany. Born and raised in Berlin, Manuel moved to different parts of Germany, Switzerland, and the US for his education before starting his independent research group in Frankfurt. He is an expert in gene editing technologies and CRISPR-based perturbation screens. His research focuses on combinatorial gene effects in cell cycle control and developing technological and computational methods accompanying these investigations. His gene editing inventions led him to co-found the biotech company Vivlion which provides CRISPR reagents and services to the global R&D market.
Relevant Publications
- ReCo: automated NGS read‑counting of single and combinatorial CRISPR gRNAsWegner M., Kaulich M., Bioinformatics (2023).
- Minimized combinatorial CRISPR screens identify genetic interactions in autophagyDiehl V., Wegner M., Grumati P., Husnjak K., Schaubeck S., Gubas A., Shah V.J., Polat I.H., Langschied F., Prieto-Garcia C., Müller K., Kalousi A., Ebersberger I., Brandts C.H., Dikic I., Kaulich M., Nucleic Acids Research (2021).
- Optimized metrics for orthogonal combinatorial CRISPR screensCetin R., Wegner M., Luwisch L., Saud S., Achmedov T., Süsser S., Vera-Guapi A., Müller K., Matthess Y., Quandt E., Schaubeck S., Beisel C.L., Kaulich M., Scientific Reports (2023).
- Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagyMichaelis J.B., Brunstein M.E., Bozkurt S., Alves L., Wegner M., Kaulich M., Pohl C., Münch C., Nature Communications (2022).
- Computational prediction of CRISPR-impaired non-coding regulatory regionsBaumgarten N., Schmidt F., Wegner M., Hebel M., Kaulich M., Schulz M.H., Biological Chemistry (2021).
- A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transitionKaulich M., Link V.M., Lapek J.D. Jr., Lee Y.J., Glass C.K., Gonzalez D.J., Dowdy S.F., Scientific Reports (2021).
- Control of endothelial quiescence by FOXO-regulated metabolitesAndrade J., Shi C., Costa A.S.H., Choi J., Kim J., Doddaballapur A., Sugino T., Ong Y.T., Castro M., Zimmermann B., Kaulich M., Guenther S., Wilhelm K., Kubota Y., Braun T., Koh G.Y., Grosso A.R., Frezza C., Potente M., Nature Cell Biology (2021).
- Unbiased and tailored CRISPR/Cas gRNA libraries by synthesizing covalently-closed-circular (3Cs) DNAWegner M., Husnjak K., Kaulich M., Bio-protocol (2020).
- Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genomeWegner M., Diehl V., Bittl V., de Bruyn R., Wiechmann S., Matthess Y., Hebel M., Hayes M.G.B., Schaubeck S., Benner C., Heinz S., Bremm A., Dikic I., Ernst A., Kaulich M., eLife (2019).
- DGK and DZHK position paper on genome editing: basic science applications and future perspectiveBrandes R.P., Dueck A., Engelhardt S., Kaulich M., Kupatt C., De Angelis M.T., Leisegang M.S., le Noble F., Moretti A., Müller O.J., Skryabin B.V., Thum T., Wurst W., Basic Research in Cardiology (2021).