Maximilian Billmann

University of Bonn, University Hospital Bonn

Biography

We explore how genes interact in networks to regulate cells. We are particularly interested to learn how such functional interactions respond to environmental changes and how this functional capacity is impacted by disease-associated genetic variants. To this end, we develop computational methods to infer mechanistic cues from of large-scale perturbation data such as the Cancer Dependency Map (DepMap), single-cell-based CRISPR experiments, the currently ongoing human Genetic Interaction Network (GIN) or tissue type-resolved expression atlases. Our methods aim at understanding and utilizing different types of perturbation data, improving data reproducibility and guide experimental efforts to maximize the information gain towards a DepMap that covers genetic, environmental and phenotypic complexity of a cancer cell.

Relevant Publications

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Varland S., Silva R.D., Kjosas I., et al., Nature Communications (2023).
Dimensionality reduction methods for extracting functional networks from large-scale CRISPR screens

Hassan A.Z., Ward H.N., Rahman M., Billmann M., Lee Y., Myers C.L., Molecular Systems Biology (2023).
Reproducibility metrics for CRISPR screens

Billmann M.+, Ward H.N., Aregger M., et al., Cell Systems (2023).
Major functional bias for mitochondrial complexes in genome-wide CRISPR screens

Rahman M.*, Billmann M.*,+, Costanzo M., et al., Molecular Systems Biology (2021).
Systematic mapping of genetic interactions for de novo fatty acid synthesis

Aregger M.*, Lawson K.*, Billmann M.*, Costanzo M., et al., Nature Metabolism (2020).
Systematic multi-site genomic editing using a CRISPR-Cas platform reveals gene paralog interactions and essential alternative exons

Gonatopoulos-Pourzatzis T., Aregger M., Brown K.R., et al., Nature Biotechnology (2020).
Widespread rewiring of genetic networks upon cancer signaling pathway activation

Billmann M., Chaudhary V., ElMaghraby M., Fischer B., Boutros M., Cell Systems (2018).
A global genetic interaction network maps a wiring diagram of cellular function

Costanzo M., VanderSluis B., Koch E.N., Baryshnikova A., et al., Science (2016).
A genetic interaction map of cell cycle modulators

Billmann M.*, Horn T.*, Fischer B., Sandmann T., Huber W., Boutros M., Molecular Biology of the Cell (2016).
A directed, epistatic map of chromatin biology and signal transduction in a metazoan cell

Fischer B.*, Sandmann T.*, Horn T.*, Billmann M.*, Chaudhary V., Huber W., Boutros M., Elife (2015).