Piero Carninci

Human Technopole

Biography

Dr Piero Carninci is a world-leading geneticist, currently Head of the Genomics Research Centre – Functional Genomics Programme at Fondazione Human Technopole in Milan (IT) and Team Leader for Laboratory for Transcriptome Technology at the RIKEN Centre for Integrative Medical Sciences in Yokohama (JP). Piero is responsible for the creation and development of various new technologies for DNA and RNA sequencing and analysis. He has led many large-scale international initiatives, including FANTOM, ENCODE and the Human Cell Atlas. He has published more than 400 papers and he is inventor of 63 patents, including a family of patents on antisense RNA than enhance protein translation (SINEUP RNAs). He is one of the co-founders of TranSINE Therapeutics, now known as Harness Therapeutics, a UK biotechnology company developing a novel class of therapeutic RNAs based on its pioneering SINEUP platform technology.

Relevant Publications

Decryption of sequence, structure, and functional features of SINE repeat elements in SINEUP non-coding RNA-mediated post-transcriptional gene regulation

Sharma H., Valentine M.N.Z., Toki N., et al., Nature Communications (2024).
The status of the human gene catalogue

Amaral P., Carbonell-Sala S., De La Vega F.M., et al., Nature (2023).
Recombination of repeat elements generates somatic complexity in human genomes

Pascarella G., Hon C.C., Hashimoto K., et al., Cell (2022).
RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

Bonetti A., Agostini F., Suzuki A.M., et al., Nature Communications (2020).
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

Hashimoto K., Kouno T., Ikawa T., et al., Proceedings of the National Academy of Sciences USA (2019).
Functional annotation of human long noncoding RNAs via molecular phenotyping

Ramilowski J.A., Yip C.W., Agrawal S., et al., Genome Research (2020).
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

Arner E., Daub C.O., Vitting-Seerup K., et al., Science (2015).
CAGE profiling of ncRNAs in hepatocellular carcinoma reveals widespread activation of retroviral LTR promoters in virus-induced tumors

Hashimoto K., Suzuki A.M., Dos Santos A., et al., Genome Research (2015).
A promoter-level mammalian expression atlas

FANTOM Consortium, Forrest A.R., Kawaji H., et al., Nature (2014).
An atlas of active enhancers across human cell types and tissues

Andersson R., Gebhard C., Miguel-Escalada I., et al., Nature (2014).