Roberta Esposito

University of Bern

Biography

Roberta Esposito is a molecular biologist and senior scientist at the Department for Biomedical Research, University of Bern, where she leads a cancer genomics research program focused on long non-coding RNAs (lncRNAs). Her work integrates CRISPR-based functional screens, transcriptomic analyses, and patient-derived organoid models to identify non-coding RNA–driven vulnerabilities in solid tumors. A central aim of her research is to translate these discoveries into RNA-based therapeutic strategies, including antisense oligonucleotide approaches for treatment-resistant cancers.

Relevant Publications

Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities

Esposito R., Polidori T., Meise D. F., Pulido-Quetglas C., Chouvardas P., Forster S., Schaerer P., Kobel A., Schlatter J., Kerkhof E., Roemmele M., Rice E. S., Zhu L., Lanzós A., Guillen-Ramirez H. A., Basile G., Carrozzo I., Vancura A., Ullrich S., Andrades Á., Harvey D., Medina P. P., Ma P. C., Haefliger S., Wang X., Martinez I., Ochsenbein A. F., Riether C., Johnson R., Cancer Genomics (2022).
New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma

Costa V., Esposito R., Ziviello C., Sepe R., Valdemarin Bim L., Cacciola N. A., Decaussin-Petrucci M., Pallante P., Fusco A., Ciccodicola A., Oncotarget (2015).