Sumana Sharma
University of Oxford
Biography
I am a Sir Henry Wellcome Postdoctoral Fellow at The MRC Weatherall Institute of Molecular Medicine in Oxford. I am interested in studying how cells respond to extracellular cues using systems-level approaches. This interest started during in my PhD at the Wellcome Sanger Institute, where I developed a genetic-screening method to identify cellular pathways required for cell surface recognition. During my post-doc at EMBL-EBI, I utilised multi-omics and CRISPR datasets to define core- and context-specific dependencies of a cell. Currently, I am studying the mechanism of inhibitory receptor (e.g PD1) signalling in T cells using genetic screening approaches. I am also interested in defining the immune dependencies of cancer cells.
Relevant Publications
- A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cellsSharma S., Whitehead T., Kotowski M., Ng E. Q. Z., Clarke J., Leitner J., Chen Y.-L., Santos A. M., Steinberger P., Davis S. J., Life Sci Alliance (2023).
- CEN-tools: An integrative platform to identify the contexts of essential genesSharma S., Dincer C., Weidemueller P., Wright G. J., Petsalaki E., Molecular Systems Biology (2020).
- Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-BVoegtle T., Sharma S., Nagy Z., Mori J., Semeniak D., Geer M. J., Smith C. W., Lane J., Pollack S., Lassila R., Jouppila A., Barr A. J., Ogg D. J., Howard T. D., McMiken H. J., Warwicker J., Geh C., Rowlinson R., Abbott M., Schulze H., Wright G. J., Mazharian A., Fuetterer K., Rajesh S., Douglas M. R., Senis Y. A., eLife (2019).
- Large-scale datasets uncovering cell signalling networks in cancer: context mattersSharma S., Petsalaki E., Current Opinion in Genetics & Development (2019).
- Genome-scale identification of cellular pathways required for cell surface recognitionSharma S., Bartholdson S. J., Couch A. C. M., Yusa K., Wright G. J., Genome Research (2018).
- Application of CRISPR-Cas9 based genome-wide screening approaches to study cellular signalling mechanismsSharma S., Petsalaki E., International Journal of Molecular Sciences (2018).